Severe allergic reaction may occur but is very rare. Lymphadenopathy has been reported as being rare. The most common reported side effects for the COVID-19 vaccine are similar to those reported in other vaccines in general, including pain in the injection site, fatigue, headaches, fever, chills, and muscle and joint pains. This vaccine is given as a set of two injections separated in time by at least 21 days. The Pfizer-BioNTech COVID-19 vaccine was the first to receive FDA approval. This spike protein is recognized by the body as an antigen provoking an immune response with the production of T-lymphocytes and B-lymphocytes targeted to destroy this specific antigen and allow for future immunity against the same pathogen. COVID-19 mRNA vaccines currently approved for use by the FDA contain particles of mRNA that when injected to the body instruct our body’s cells to produce spike protein, a harmless surface protein unique to SARS-CoV-2, the COVID-19 virus. Although mRNA vaccine technology is relatively new compared to the long history of conventional vaccines to key pathogen proteins, it has been investigated during the last three decades on several viruses such as influenza, rabies, CMV (cytomegalovirus), and Zika. The coronavirus disease 2019 (COVID-19) worldwide pandemic outbreak has engendered substantial research, manufacture, and use of messenger RNA (mRNA) vaccines. Accordingly, to our knowledge, this is the first report describing post-COVID-19 vaccine lymphadenopathy detailing the clinical aspects, sonographic features, and outcomes. Time elapsed from the injection until the appearance of the enlarged nodes, clinical symptoms, and sonographic features differed between the patients, but in all cases gradual regression was noted in the enlarged nodes until complete resolution. Here, we present the cases of three patients who developed lymphadenopathy after the first dose of Pfizer-BioNTech COVID-19 vaccine. Israel has been cited as leading in the introduction of these vaccines, which are available for every citizen older than 16 years. Specifically, lymphadenopathy has not been considered a common manifestation of COVID-19 vaccination.
Known side effects for this vaccine have been reported as very similar to those known for other vaccines. These vaccines are based on messenger RNA novel technology and considered efficient in preventing contagion ensuring safety. Pfizer-BioNTech COVID-19 vaccine followed by Moderna COVID-19 mRNA-1273 vaccine were the first to receive FDA approval. Researchers and pharmaceutical companies around the globe have been racing to develop potent and safe vaccines for the disease. The disease had spread quickly throughout the world causing extensive, widespread morbidity, over two million deaths, and economical and social devastation over the entire world. The coronavirus disease 2019 (COVID-19) pandemic has dominated nearly everyone’s life since its initial outbreak in the Hubei province of China in December 2019.
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